Make Medicines Affordable partner, the Initiative for Medicines, Access and Knowledge (I-MAK), has produced the Roadmap Special Edition Report on Tenofovir Alafenamide Fumarate (TAF). This report expands on the information provided in the original Roadmap, and most importantly, aims to provide the international community with critical analysis well in advance of when policy-makers will have to determine how TAF may be used in HIV treatment programs.